NAD+: A whole-body approach to anti-aging

As our clients seek to slow the aging process at a whole-body level, Bespoke is expanding its services into lifestyle “medicine” and  wellness modalities, products and services. NAD+ and Glutathione are two of our most popular longevity injections and supplements.

Did you know our NAD+ levels decline by ~50% every 20 years and this decline is known to be a key driver of the aging process?   Many people who are experiencing signs and symptoms of aging such as reduced mental and physical energy, brain fog, poor sleep and symptoms of menopause.

NAD+ is found in every cell in the body so the benefits of increasing NAD+ are vast. Increasing NAD+ levels can improve mitochondrial function, support immune function, increase DNA damage repair, increase energy metabolism, enhance muscle function, improve cognitive function and improve markers of metabolic health, all of which positively influence healthspan.

 An injection or supplement to aid recovery and reduce downtime

Many non-surgical aesthetic treatments such as micro needling, chemical peels and laser resurfacing induce cellular damage and the results of these treatments rely upon adequate cellular repair mechanisms to stimulate cellular regeneration.

NAD+ is known to power many cellular repair and regeneration pathways to boost recovery and reduce downtime after invasive procedures. NAD+ also stimulates skin cell repair and supports the production of collagen and elastin. In this manner, NAD+ injections or supplements can be used before procedures to ensure cells are in optimal condition to respond to the treatment and after procedures to support recovery.

This is especially important for more mature patients receiving invasive treatments because the skin's regenerative capacity and NAD+ both decline with age, meaning a higher risk of increased recovery times.

Increase the regenerative capacity of cells

Skin aging occurs because of key changes at a cellular level, termed the ‘Hallmarks of Aging’. These changes prevent optimal cellular function leading to the accumulation of cellular damage, which results in the physical signs of skin aging such as reduction in skin elasticity, wrinkles and reduced wound healing. Aging begins at a cellular level, so any true rejuvenation treatment must target these key cellular changes.

The 9 Hallmarks of Aging include:

1. Genomic Instability: Over time, our DNA can get damaged by various factors like UV rays, pollution, and normal cellular processes. This damage accumulates, leading to mutations and other issues that contribute to aging and disease.
2. Epigenetic Alterations: Our genes can be turned on or off by various environmental and lifestyle factors. As we age, these changes can accumulate and disrupt normal cellular function, leading to various age-related conditions.
3. Mitochondrial Dysfunction: Mitochondria are the powerhouses of our cells, producing the energy they need to function. As we age, mitochondria become less efficient and generate more harmful byproducts, leading to decreased energy and increased cellular damage.
4. Deregulated Nutrient Sensing: Our cells have systems in place to detect and respond to nutrients. With age, these systems can become less effective, leading to issues like insulin resistance, metabolic syndrome, and other age-related metabolic disorders.
5. Telomere Attrition: Telomeres are protective caps at the ends of our chromosomes that shorten each time a cell divides. Over time, they become too short to protect the chromosomes, leading to cellular aging and dysfunction.
6. Cellular Senescence: Senescent cells are old or damaged cells that stop dividing but don't die off. They can secrete harmful substances that cause inflammation and tissue damage, contributing to aging and age-related diseases.
7. Chronic Inflammation: As we age, our bodies can develop a state of low-level, chronic inflammation. This persistent inflammation can damage tissues and organs, playing a key role in many age-related diseases.
8. Stem Cell Exhaustion: Stem cells are responsible for repairing and regenerating tissues. As we age, the number and function of stem cells decline, leading to reduced tissue repair and regeneration, and contributing to aging.
9. Disabled Autophagy: Autophagy is the process by which cells clean out damaged components and recycle them. With age, this process becomes less efficient, leading to the accumulation of cellular waste and damaged components, which can impair cellular function.

NAD+ is one of the only molecules known to positively target all of the Hallmarks of Aging to restore cellular health. If you're ready to rejuvenate your body and mind with professional NAD+ therapy, contact us today. The Bespoke Beauty team is here to provide you with the highest quality care and personalized attention. You can easily get a free consultation by booking online or give us a call to discuss your needs and schedule an appointment. We are also available via email for any questions or additional information.